Heating Up

Cancer Treatment

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Turn cold tumors hot

Immunosuppressive elements in the tumor microenvironment mean that many tumors evade treatment and are hidden from cancer-destroying immune cells. Tumors are considered “hot” or “cold.” Hot tumors contain many T cells (T-cell inflamed), whereas cold tumors have immunosuppressive elements that exclude T cells. This distinction is crucial because some T cells can recognize and eliminate cancerous cells.

Cold tumors make up the majority of cancers and affect 5 times as many patients as hot tumors. Because cold tumors have unique immunosuppressive characteristics, immunotherapy is only minimally effective in treating these cancers.

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